CD4 CLIA Kit for Human(Homo sapiens) | EIAab.comCD4 CLIA Kit for Human(Homo sapiens)

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CD4 (Gene name),

T-cell surface glycoprotein CD4 (Protein name ), CD4_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CD4;

Protein name:

T-cell surface glycoprotein CD4;

Alternative:

T-cell surface antigen T4/Leu-3;

CD:

CD4;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins. Interacts with PTK2; this interaction requires the presence of HIV-1 gp120.

Function:

Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.

Subcellular Location:

Cell membrane Single-pass type I membrane protein Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.

Protein Attributes:

Sequence length:

458

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

458:

FQKTCSPI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

186940

KEGG:

hsa:920

SMR:

P01730

STRING:

9606.ENSP00000011653

UniGene:

Hs.631659

String:

P01730

Pfam:

PF05790

Uniprot:

P01730

FOR

ELISA Kit for Human T-cell surface glycoprotein CD4

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E1014h

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96T

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ELISA Kit for Human T-cell surface glycoprotein CD4

Cat.:

E1014r

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96T

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ELISA Kit for Human T-cell surface glycoprotein CD4

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ELISA Kit for Human T-cell surface glycoprotein CD4

Cat.:

E1014m

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96T

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ELISA Kit for Human T-cell surface glycoprotein CD4

Cat.:

E1014d

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96T

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CLIA Kit for Human T-cell surface glycoprotein CD4

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CLIA Kit for Human T-cell surface glycoprotein CD4

Cat.:

U1014r

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human T-cell surface glycoprotein CD4

Cat.:

U1014h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

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CLIA Kit for Human T-cell surface glycoprotein CD4

Cat.:

U1014m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human T-cell surface glycoprotein CD4

Cat.:

U1014d

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96T

Polyclonal Antibody for Human T-cell surface glycoprotein CD4

Cat.:

P1014Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human T-cell surface glycoprotein CD4

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P1014Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human T-cell surface glycoprotein CD4

Cat.:

P1014Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human T-cell surface glycoprotein CD4

Monoclonal Antibody for Human T-cell surface glycoprotein CD4

Protein for Human T-cell surface glycoprotein CD4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family."
Maddon P.J. , Littman D.R. , Godfrey M. , Maddon D.E. , Chess L. , Axel R.
Cell42:93-104(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Corrected CD4 sequence."
Littman D.R. , Maddon P.J. , Axel R.
Cell55:541-541(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 26
3.

"A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13."
Ansari-Lari M.A. , Muzny D.M. , Lu J. , Lu F. , Lilley C.E. , Spanos S. , Malley T. , Gibbs R.A.
Genome Res.6:314-326(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination."
Ansari-Lari M.A. , Shen Y. , Muzny D.M. , Lee W. , Gibbs R.A.
Genome Res.7:268-280(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue: Brain.
5.

"Humans with OKT4-epitope deficiency have a single nucleotide base change in the CD4 gene, resulting in substitution of TRP240 for ARG240."
Hodge T.W. , Sasso D.R. , McDougal J.S.
Hum. Immunol.30:99-104(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];POLYMORPHISM;VARIANT TRP-265
6.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
7.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Thymus.
8.

NIEHS SNPs program
Submitted (2005-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLU-191; SER-227 AND TRP-265
9.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Pancreas.
11.

"Cloning and sequences of primate CD4 molecules: diversity of the cellular receptor for simian immunodeficiency virus/human immunodeficiency virus."
Fomsgaard A. , Hirsch V.M. , Johnson P.R.
Eur. J. Immunol.22:2973-2981(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 28-424
tissue: Blood.
12.

"Protein and carbohydrate structural analysis of a recombinant soluble CD4 receptor by mass spectrometry."
Carr S.A. , Hemling M.E. , Folena-Wasserman G. , Sweet R.W. , Anumula K. , Barr J.R. , Huddleston M.J. , Taylor P.
J. Biol. Chem.264:21286-21295(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 26-394;DISULFIDE BOND
13.

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z. , Henzel W.J.
Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 26-40
14.

"A single amino acid substitution in a common African allele of the CD4 molecule ablates binding of the monoclonal antibody, OKT4."
Lederman S. , DeMartino J.A. , Daugherty B.L. , Foeldvari I. , Yellin M.J. , Cleary A.M. , Berkowitz N. , Lowy I. , Braunstein N.S. , Mark G.E.
Mol. Immunol.28:1171-1181(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 250-280;POLYMORPHISM;VARIANT TRP-265
15.

"CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor."
Crise B. , Buonocore L. , Rose J.K.
J. Virol.64:5585-5593(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIV-1 ENVELOPE POLYPROTEIN GP160
16.

"Carbohydrate structures of recombinant soluble human CD4 expressed in Chinese hamster ovary cells."
Spellman M.W. , Leonard C.K. , Basa L.J. , Gelineo I. , van Halbeek H.
Biochemistry30:2395-2406(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-296 AND ASN-325
17.

"Identification of palmitoylation sites on CD4, the human immunodeficiency virus receptor."
Crise B. , Rose J.K.
J. Biol. Chem.267:13593-13597(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION AT CYS-419 AND CYS-422
18.

"Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain."
Aiken C. , Konner J. , Landau N.R. , Lenburg M.E. , Trono D.
Cell76:853-864(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REMOVAL FROM CELL SURFACE BY HIV-1 NEF;MUTAGENESIS OF MET-432; SER-433; 438-LEU-LEU-439 AND SER-440
19.

"CD4 is a critical component of the receptor for human herpesvirus 7: interference with human immunodeficiency virus."
Lusso P. , Secchiero P. , Crowley R.W. , Garzino-Demo A. , Berneman Z.N. , Gallo R.C.
Proc. Natl. Acad. Sci. U.S.A.91:3872-3876(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HUMAN HERPESVIRUS 7 CAPSID PROTEINS
20.

"Cloning of ACP33 as a novel intracellular ligand of CD4."
Zeitlmann L. , Sirim P. , Kremmer E. , Kolanus W.
J. Biol. Chem.276:9123-9132(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SPG21;MUTAGENESIS OF 457-PRO-ILE-458
21.

"Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling."
Fragoso R. , Ren D. , Zhang X. , Su M.W. , Burakoff S.J. , Jin Y.J.
J. Immunol.170:913-921(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
22.

"Protein minimization of the gp120 binding region of human CD4."
Sharma D. , Balamurali M.M. , Chakraborty K. , Kumaran S. , Jeganathan S. , Rashid U. , Ingallinella P. , Varadarajan R.
Biochemistry44:16192-16202(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIV-1 SURFACE PROTEIN GP120
23.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-296
tissue: Liver.
24.

"Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains."
Wang J. , Yan Y. , Garrett T.P. , Liu J. , Rodgers D.W. , Garlick R.L. , Tarr G.E. , Husain Y. , Reinherz E.L. , Harrison S.C.
Nature348:411-418(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 26-208
25.

"Crystal structure of an HIV-binding recombinant fragment of human CD4."
Ryu S.-E. , Kwong P.D. , Truneh A. , Porter T.G. , Arthos J. , Rosenberg M. , Dai X. , Xuong N.-H. , Axel R. , Sweet R.W. , Hendrickson W.A.
Nature348:419-426(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 26-208
26.

"Dimeric association and segmental variability in the structure of human CD4."
Wu H. , Kwong P.D. , Hendrickson W.A.
Nature387:527-530(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.9 ANGSTROMS) OF 26-388
27.

"Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody."
Kwong P.D. , Wyatt R. , Robinson J. , Sweet R.W. , Sodroski J. , Hendrickson W.A.
Nature393:648-659(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 26-208 IN COMPLEX WITH HIV SURFACE PROTEIN GP120
28.

"Structural basis for the interaction between focal adhesion kinase and CD4."
Garron M.L. , Arthos J. , Guichou J.F. , McNally J. , Cicala C. , Arold S.T.
J. Mol. Biol.375:1320-1328(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.82 ANGSTROMS) OF 428-450 IN COMPLEX WITH PTK2/FAK1;INTERACTION WITH PTK2/FAK1

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